Rivalry file · 2021–2026 · regular season + playoffs
San Francisco 49ers lead 7-4 in this window.
Arizona Cardinals
4-7
254 points for
Split
Regular season: 4-7
Playoffs: 0-0
11 games
San Francisco 49ers
7-4
323 points for
The case against
The Arizona Cardinals went 4-7 vs San Francisco 49ers, 2021–2026 regular season + playoffs.
The Arizona Cardinals posted a scoring margin of −6.3 per game vs San Francisco 49ers, 2021–2026 regular season + playoffs.
The case against
No strong case on this side.
The head-to-head numbers do not go against this team in this window. We don’t manufacture parity.
| Date | Game | Result |
|---|---|---|
| Sep 27, 2026 | Week 3 · Cardinals at 49ers | 30–36 |
| Nov 16, 2025 | Week 11 · 49ers at Cardinals | 41–22 |
| Sep 21, 2025 | Week 3 · Cardinals at 49ers | 15–16 |
| Jan 5, 2025 | Week 18 · 49ers at Cardinals | 24–47 |
| Oct 6, 2024 | Week 5 · Cardinals at 49ers | 24–23 |
| Dec 17, 2023 | Week 15 · 49ers at Cardinals | 45–29 |
| Oct 1, 2023 | Week 4 · Cardinals at 49ers | 16–35 |
| Jan 8, 2023 | Week 18 · Cardinals at 49ers | 13–38 |
| Nov 21, 2022 | Week 11 · 49ers at Cardinals | 38–10 |
| Nov 7, 2021 | Week 9 · Cardinals at 49ers | 31–17 |
| Oct 10, 2021 | Week 5 · 49ers at Cardinals | 10–17 |
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